State Road 80 is a 123.5 miles (198.8 km) route linking US 41 Business in Fort Myers and State Road A1A in Palm Beach. The road is the northernmost of three linking Southwest Florida to South Florida via the Everglades. Due to increasing traffic, State Road 80 has experienced upgrades and widening in various sections since 2000.

Lee County is located in southwestern Florida, United States, on the Gulf Coast. As of the 2020 census, its population was 760,822. In 2022, the population was 822,453, making it the eighth-most populous county in the state. The county seat is Fort Myers, with a population of 86,395 as of the 2020 census, and the largest city is Cape Coral, with an estimated 2020 population of 194,016.