The term "folio" has three interconnected but distinct meanings in the world of books and printing: first, it is a term for a common method of arranging sheets of paper into book form, folding the sheet only once, and a term for a book made in this way; second, it is a general term for a sheet, leaf or page in (especially) manuscripts and old books; and third, it is an approximate term for the size of a book, and for a book of this size.

Printing is a process for mass reproducing text and images using a master form or template. The earliest non-paper products involving printing include cylinder seals and objects such as the Cyrus Cylinder and the Cylinders of Nabonidus. The earliest known form of printing evolved from ink rubbings made on paper or cloth from texts on stone tablets, used during the sixth century. Printing by pressing an inked image onto paper appeared later that century. Later developments in printing technology include the movable type invented by Bi Sheng around 1040 AD and the printing press invented by Johannes Gutenberg in the 15th century. The technology of printing played a key role in the development of the Renaissance and the Scientific Revolution and laid the material basis for the modern knowledge-based economy and the spread of learning to the masses.