Forsyth County is located in the northwest Piedmont of the U.S. state of North Carolina. As of the 2020 census, the population was 382,590, making it the fourth-most populous county in North Carolina. Its county seat is Winston-Salem. Forsyth County is part of the Winston-Salem, NC, Metropolitan Statistical Area, which is also included in the Greensboro–Winston-Salem–High Point, NC, Combined Statistical Area. Portions of Forsyth County are in the Yadkin Valley wine region.

Winston-Salem is a city in and the county seat of Forsyth County, North Carolina, United States. At the 2020 census, the population was 249,545, making it the fifth-most populous city in North Carolina, and the 90th-most populous city in the United States. The population of the Winston-Salem metropolitan area was estimated to be 695,630 in 2023. It is the second-most populous city in North Carolina's Piedmont Triad region, home to about 1.7 million residents.