Fort Cépérou was a fort that protected the city of Cayenne, French Guiana. It is named after Cépérou, a celebrated indigenous chief who ceded the land.

Cayenne is the prefecture of French Guiana, an overseas region and department of France located in South America. The city stands on a former island at the mouth of the Cayenne River on the Atlantic coast. The city's motto is "fert aurum industria", which means "work brings wealth". Cayenne is the largest Francophone city of the South American continent.