Fort Deposit is a town in Lowndes County, Alabama, United States. Since 1890, it has been the largest town in Lowndes County. At the 2010 census the population was 1,344, up from 1,270 in 2000. It is part of the Montgomery Metropolitan Statistical Area.

Lowndes County is in the central part of the U.S. state of Alabama. As of the 2020 census, the county's population was 10,311. Its county seat is Hayneville. The county is named in honor of William Lowndes, a member of the United States Congress from South Carolina.