Fort Raleigh National Historic Site preserves the location of Roanoke Colony, the first English settlement in the present-day United States. The site was preserved for its national significance in relation to the founding of the first English settlement in North America in 1587. The colony, which was promoted and backed by entrepreneurs led by Englishman Sir Walter Raleigh, failed sometime between 1587 and 1590 when supply ships failed to arrive on time. When next visited, the settlement was abandoned with no survivors found. The fate of the "Lost Colony" was a celebrated mystery, although most modern academic sources agree that the settlers likely assimilated into local indigenous tribes.

Wright Brothers National Memorial, located in Kill Devil Hills, North Carolina, commemorates the first successful, sustained, powered flights in a heavier-than-air machine. From 1900 to 1903, Wilbur and Orville Wright came here from Dayton, Ohio, based on information from the U.S. Weather Bureau about the area's steady winds. They also valued the privacy provided by this location, which in the early twentieth century was remote from major population centers.