The Fourth Macedonian War was fought between Macedon, led by the pretender Andriscus, and the Roman Republic. It was the last of the Macedonian Wars, and was the last war to seriously threaten Roman control of Greece until the First Mithridatic War sixty years later.

Macedonia, also called Macedon, was an ancient kingdom on the periphery of Archaic and Classical Greece, which later became the dominant state of Hellenistic Greece. The kingdom was founded and initially ruled by the royal Argead dynasty, which was followed by the Antipatrid and Antigonid dynasties. Home to the ancient Macedonians, the earliest kingdom was centered on the northeastern part of the Greek peninsula, and bordered by Epirus to the southwest, Illyria to the northwest, Paeonia to the north, Thrace to the east and Thessaly to the south.