The Fox–Wisconsin Waterway is a waterway formed by the Fox and Wisconsin Rivers. First used by European settlers in 1673 during the expedition of Marquette & Joliet, it was one of the principal routes used by travelers between the Great Lakes and the Mississippi River until the completion of the Illinois and Michigan Canal in 1848 and the arrival of railroads. The western terminus of the Fox–Wisconsin Waterway was at the Mississippi at Prairie du Chien, Wisconsin. It continued up the Wisconsin River about 116 miles (187 km) until reaching Portage, Wisconsin. There travelers would portage to the Upper Fox River, or eventually, use the Portage Canal. It continued about 160 miles (260 km) down the Fox River, following it through Lake Winnebago and continuing on the Lower Fox over 170 feet of falls to the eastern terminus of Green Bay.

The Fox River is a river in eastern Wisconsin in the Great Lakes region of the United States. It is the principal tributary of Green Bay, and via the Bay, the largest tributary of Lake Michigan. The city of Green Bay, one of the first European settlements in the interior of North America, is on the river at its mouth on lower Green Bay.