Francesco Barbaro (1390–1454) was an Italian politician, diplomat, and humanist from Venice and a member of the patrician Barbaro family. He is interred in the Church of the Frari, Venice.

The Barbaro family was a patrician family of Venice. They were wealthy and influential and owned large estates in the Veneto above Treviso. Various members were noted as church leaders, diplomats, patrons of the arts, military commanders, philosophers, scholars, and scientists.