Admiral Francis Holburne was a Royal Navy officer and politician. He served as commodore and commander-in-chief at the Leeward Islands during the War of the Austrian Succession and then took part in an operation to capture Louisbourg as part of the Louisbourg Expedition during the Seven Years' War. He went on to be Port Admiral at Portsmouth and then Senior Naval Lord. In retirement he became Governor of Greenwich Hospital. He also served as a Member of Parliament.

The Commander-in-Chief, Portsmouth, was a senior commander of the Royal Navy for hundreds of years. The commanders-in-chief were based at premises in High Street, Portsmouth from the 1790s until the end of Sir Thomas Williams's tenure, his successor, Sir Philip Durham, being the first to move into Admiralty House at the Royal Navy Dockyard, where subsequent holders of the office were based until 1969. Prior to World War I the officer holder was sometimes referred to in official dispatches as the Commander-in-Chief, Spithead.