The Franco-Ottoman alliance, also known as the Franco-Turkish alliance, was an alliance established in 1536 between Francis I, King of France and Suleiman I of the Ottoman Empire. The strategic and sometimes tactical alliance was one of the longest-lasting and most important foreign alliances of France, and was particularly influential during the Italian Wars. The Franco-Ottoman military alliance reached its peak with the Invasion of Corsica of 1553 during the reign of Henry II of France.

Francis I was King of France from 1515 until his death in 1547. He was the son of Charles, Count of Angoulême, and Louise of Savoy. He succeeded his first cousin once removed and father-in-law Louis XII, who died without a legitimate son.