Franco Dino Rasetti was an Italian physicist, paleontologist and botanist. Together with Enrico Fermi, he discovered key processes leading to nuclear fission. Rasetti refused to work on the Manhattan Project on moral grounds.

Enrico Fermi was an Italian and later naturalized American physicist, renowned for being the creator of the world's first nuclear reactor, the Chicago Pile-1, and a member of the Manhattan Project. He has been called the "architect of the nuclear age" and the "architect of the atomic bomb". He was one of very few physicists to excel in both theoretical physics and experimental physics. Fermi was awarded the 1938 Nobel Prize in Physics for his work on induced radioactivity by neutron bombardment and for the discovery of transuranium elements. With his colleagues, Fermi filed several patents related to the use of nuclear power, all of which were taken over by the US government. He made significant contributions to the development of statistical mechanics, quantum theory, and nuclear and particle physics.