Frank–Starling law
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The Frank–Starling law of the heart represents the relationship between stroke volume and end diastolic volume. The law states that the stroke volume of the heart increases in response to an increase
In cardiomyocytes, sarcomere stretch decreases the distance between the thin filament (actin) and the thick filament (myosin). This which leads to increased cross-bridge formation and greater tension.
Myofilament
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Myofilaments are the three protein filaments of myofibrils in muscle cells. The main proteins involved are myosin, actin, and titin. Myosin and actin are the contractile proteins and titin is an elast
Frank–Starling law
…of there being less overlap of the thin and thick filaments; for shorter sarcomere lengths, the cause is the decreased sensitivity for calcium by the myofilaments. An increase in filling of the ventricle increases the load experienced by each cardiac muscle cells, stretching their sarcomeres toward their optimal…
Muscle fiber showing thick and thin myofilaments of a myofibril.