Frankfurt-Zeilsheim station is a railway station located in the Sindlingen district of Frankfurt, Germany, on the Main-Lahn Railway. It is served by line S2 of the Rhine-Main S-Bahn. The station opened on 13 May 2007 and is classified by Deutsche Bahn as a category 5 station.

The Main-Lahn railway, also called the Limburg railway, is a double-track, electrified main railway line in Germany. The 66.5-kilometer (41.3 mi) long line extends from Frankfurt Central Station (Hauptbahnhof) to Eschhofen, a borough of Limburg an der Lahn.