The Rhine-Main Metropolitan Region, often simply referred to as Frankfurt Rhine-Main, Frankfurt Rhine-Main area or Rhine-Main area, is the second-largest metropolitan region in Germany after Rhine-Ruhr, with a total population exceeding 5.8 million. The metropolitan region is located in the central-western part of Germany, and stretches over parts of three German states: Hesse, Rhineland-Palatinate, and Bavaria. The largest cities in the region are Frankfurt am Main, Wiesbaden, Mainz, Darmstadt, Offenbach, Worms, Hanau, and Aschaffenburg.

There are eleven metropolitan regions in Germany consisting of the country's most densely populated cities and their catchment areas. They represent Germany's political, commercial and cultural centres. The eleven metropolitan regions in Germany were organised into political units for planning purposes.