Franklin County is a county located in the U.S. state of Mississippi. As of the 2020 census, the population was 7,675. Its county seat is Meadville. The county was formed on December 21, 1809, from portions of Adams County and named for Founding Father Benjamin Franklin. It is bisected by the Homochitto River, which runs diagonally through the county from northeast to southwest.

Meadville is a town in and the county seat of Franklin County, Mississippi, United States, in the southwest part of the state. The population was 449 at the 2010 census, down from 519 at the 2000 census. It is situated north of the Homochitto River, which runs from the northeast to the southwest through the county on its way to its outlet at the Mississippi River.