The Franklin River is a major perennial river located in the Central Highlands and western regions of Tasmania, Australia. The river is located in the Franklin-Gordon Wild Rivers National Park at the mid northern area of the Tasmanian Wilderness World Heritage Area. Its source is situated at the western edge of the Central Highlands and it flows west towards the West Coast.

The West Coast of Tasmania is one of the regions of Tasmania in Australia. It is mainly isolated rough country and is associated with wilderness, mining and tourism. It served as the location of an early convict settlement in the early history of Van Diemen's Land, and contrasts sharply with the more developed and populous northern and eastern parts of the island state.