Fray Bentos is the capital city of the Río Negro Department, in south-western Uruguay, at the Argentina-Uruguay border, near the Argentine city of Gualeguaychú. Its port on the Uruguay River is one of the nation's most important harbours. The city hosts the first campus of the Technological University, beside the historically relevant industrial complex Anglo, a World Heritage Site.

Río Negro Department is a department of the northwestern region of Uruguay. It has an area of 9,282 km2 (3,584 sq mi) and a population of 54,765. Its capital is Fray Bentos. It borders Paysandú Department to the north, Tacuarembó Department to the east, Durazno Department to the southeast, Soriano Department to the south and has the Río Uruguay flowing at its west, separating it from Argentina.