Fray Bentos is the capital city of the Río Negro Department, in south-western Uruguay, at the Argentina-Uruguay border, near the Argentine city of Gualeguaychú. Its port on the Uruguay River is one of the nation's most important harbours. The city hosts the first campus of the Technological University, beside the historically relevant industrial complex Anglo, a World Heritage Site.

Austral Líneas Aéreas Flight 2553 was an Argentinian domestic scheduled passenger flight from Posadas to Buenos Aires. On October 10, 1997, the McDonnell Douglas DC-9-32 that was operating the flight crashed on the lands of Estancia Magallanes, Nuevo Berlín, 32 kilometres away from Fray Bentos, Uruguay. All 74 passengers and crew died upon impact. The accident remains the deadliest in Uruguayan history.