Frederick Drew Gregory is a former United States Air Force pilot, military engineer, test pilot, and NASA astronaut as well as former NASA Deputy Administrator. He also served briefly as NASA Acting Administrator in early 2005, covering the period between the departure of Sean O'Keefe and the swearing in of Michael D. Griffin.

James Monroe Gregory was a Professor of Latin and Dean at Howard University. During the American Civil War, he worked in Cleveland for the education and aid of escaped slaves. He initially attended Oberlin College. He transferred to Howard and was the valedictorian of Howard's first graduating class in 1872. He then became a member of faculty, where he served until the late 1880s. During that time he was active in civil rights, particularly related to the education of African American children. He fought to desegregate Washington, D.C., schools in the early 1880s and participated in the Colored Conventions Movement and was a delegate to the 1892 Republican National Convention. In 1890, he founded the American Association of Educators of Colored Youth. In 1893, he published a biography of Frederick Douglass. In 1897, he was removed at Howard and moved to New Jersey where he became principal of Bordentown Industrial and Manual Training School.