Frederick Philipse II was a merchant, landowner, and politician in British America. He was the only son of Maria Sparkes, daughter of the Governor of Barbados, and Philip Philipse, eldest son of Frederick Philipse I, 1st Lord of the Philipsburg Manor. Philip predeceased his father, and family lands passed on to younger son Adolphus Philipse. Upon his uncle's death Frederick II inherited his share of Philipse lands and commercial interests, thereafter becoming the elder Philipse male and 2nd Lord of Philipsburg Manor.

Philip Philipse (1663–1699) was the eldest son and heir of Frederick Philipse, a Dutch-born merchant trader, slaver, land baron, and 1st Lord of Philipsburg Manor. However, he died before his father, and by Frederick's will Philip's legacy was split between his bachelor brother Adolphus Philipse and his son Frederick Philipse II, who became the 2nd Lord of Philipse Manor.