Frederick Soddy FRS was an English radiochemist who explained, with Ernest Rutherford, that radioactivity is due to the transmutation of elements, now known to involve nuclear reactions. He also proved the existence of isotopes of certain radioactive elements. In 1921 he received the Nobel Prize in Chemistry "for his contributions to our knowledge of the chemistry of radioactive substances, and his investigations into the origin and nature of isotopes". Soddy was a polymath who mastered chemistry, nuclear physics, statistical mechanics, finance and economics.

Ernest Rutherford, 1st Baron Rutherford of Nelson, was a New Zealand physicist who was a pioneering researcher in both atomic and nuclear physics. Rutherford has been described as "the father of nuclear physics", and "the greatest experimentalist since Michael Faraday". In 1908, he was awarded the Nobel Prize in Chemistry "for his investigations into the disintegration of the elements, and the chemistry of radioactive substances." He was the first Oceanian Nobel laureate, and the first to perform the awarded work in Canada.