Free-radical theory of aging
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The free radical theory of aging, first proposed by American biogerontologist Denham Harman in the 1950s, states that organisms age because cells accumulate free radical damage over time. A free radic
In chemistry, a free radical is any atom, molecule or ion with an unpaired valence electron.
Major sources of reactive oxygen species in living systems
Reactive oxygen species
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In chemistry and biology, reactive oxygen species are highly reactive chemicals formed from diatomic oxygen, water, and hydrogen peroxide. Some prominent ROS are the hydroperoxide radical or hydropero
Free-radical theory of aging
…there is evidence that reducing oxidative damage can extend lifespan. In the 1970s, Harman extended his theory to implicate mitochondrial production of reactive oxygen species. Whether reducing oxidative damage below normal levels counters aging remains an open question. Evidence to the contrary exists in some species. In…
The scheme of fabrication process and therapeutic mechanism of thermo-responsive (MSNs@CaO2-ICG)@LA NPs for synergistic CDT/PDT with H2O2/O2 self-supply and GSH depletion