Scipion was a 74-gun French ship of the line, built at Lorient to a design by Jacques Noel Sane. She was laid down as Orient in late 1798, and renamed Scipion in 1801. She was first commissioned in 1802 and joined the French Mediterranean fleet based at Toulon, in the squadron of Admiral Leissègues. Consequently, she was one of the ships afloat in that port when war with England reopened in May 1803. She participated in the Battle of Cape Finisterre and the Battle of Trafalgar. The British captured her in the subsequent Battle of Cape Ortegal. In 1810 she participated in the Java campaign, which in 1847 earned her surviving crew the Naval General Service Medal. She participated in the blockade of Toulon in 1813 and was paid off in 1814. She was broken up in 1819.

In the Battle of Cape Finisterre off Galicia, Spain, the British fleet under Admiral Robert Calder fought an indecisive naval battle against the combined Franco-Spanish fleet which was returning from the West Indies. In the ensuing battle the British captured two Spanish ships of the line, but failed to prevent the joining of French Admiral Pierre de Villeneuve's fleet to the squadron of Ferrol and to strike the shattering blow that would have freed Great Britain from the danger of an invasion. Calder was later court-martialled and severely reprimanded for his failure and for avoiding the renewal of the engagement on 23 and 24 July. At the same time, in the aftermath Villeneuve elected not to continue on to Brest, where his fleet could have joined with other French ships to clear the English Channel for an invasion of Great Britain.