The 1999 Fully Loaded was the second annual Fully Loaded professional wrestling pay-per-view (PPV) event produced by the World Wrestling Federation. It took place on July 25, 1999, at the Marine Midland Arena in Buffalo, New York. Although the event was the second Fully Loaded PPV held, it was the first Fully Loaded not held under the In Your House series, which had been discontinued in February 1999. Matches at the event were fought in a number of venues, including a parking garage.

KeyBank Center is a multipurpose indoor arena located in Buffalo, New York. Originally known as Marine Midland Arena, the venue has since been named HSBC Arena and First Niagara Center. Home to the Buffalo Sabres of the National Hockey League since 1996, is the largest indoor arena in Western New York, seating 19,070. It replaced the Sabres' former home, Buffalo Memorial Auditorium, where the team played from 1970 to 1996. The venue is also home to the Buffalo Bandits of the National Lacrosse League.