Fulton is a city in and the county seat of Itawamba County, Mississippi, United States. The population was 4,542 at the 2020 census.

Itawamba County is a county located in the U.S. state of Mississippi. As of the 2020 United States Census, the population was 23,863. Its county seat is Fulton. The county is part of the Tupelo, MS Micropolitan Statistical Area.