Fulton is the largest city in and the county seat of Callaway County, Missouri, United States. Located about 22 miles (35 km) northeast of Jefferson City and the Missouri River and 20 miles (32 km) east of Columbia, the city is part of the Jefferson City, Missouri, Metropolitan Statistical Area. The population was 12,600 at the 2020 census. The city is home to two universities, Westminster College and William Woods University; the Missouri School for the Deaf; the Fulton State Hospital; and the Fulton Reception and Diagnostic Center state prison. Missouri's only nuclear power plant, the Callaway Plant is located 13 miles southeast of Fulton.

The Jefferson City metropolitan statistical area, as defined by the United States Census Bureau, is an area consisting of four counties – Cole, Callaway, Moniteau, and Osage – in central Missouri anchored by the city of Jefferson City. As of the 2020 census, the MSA had a population of 150,316. The Jefferson City MSA consists of four counties, and borders the Columbia metropolitan area to the north.