Fuquay-Varina is a town in southern Wake County, North Carolina, United States, lying south of Holly Springs and southwest of Garner, and north of the Harnett County town of Angier and west of the unincorporated community of Willow Springs. The population was 17,937 at the 2010 census, and estimated at 36,736 as of July 2021. The hyphenated name attests to the town's history as two separate towns. Fuquay Springs and Varina merged in 1963 to create the modern town. Economically, the town initially grew due to tobacco trade and agriculture, but has seen recent population growth and real estate development due to its proximity to Research Triangle Park.

The Norfolk Southern Railway was the final name of a railroad that ran from Norfolk, Virginia, southwest and west to Charlotte, North Carolina. It was acquired by the Southern Railway in 1974, which merged with the Norfolk and Western Railway in 1982 to form the current Norfolk Southern Railway.