Fyffe is a town in DeKalb County, Alabama, United States. It was incorporated in 1956. At the 2020 census, the population was 967. Fyffe is located atop Sand Mountain.

DeKalb County is a county located in the northeastern part of the U.S. state of Alabama. As of the 2020 census, the population was 71,608. Its county seat is Fort Payne, and it is named after Major General Baron Johan DeKalb. DeKalb County is part of the Huntsville-Decatur-Albertville, AL Combined Statistical Area.