The Shanghai–Chongqing Expressway, designated as G50 and commonly referred to as the Huyu Expressway is an east-west bound expressway that connects the cities of Shanghai, China in Yangtze River Delta, and Chongqing in western China. The expressway runs through six provinces/municipalities and adjoin major cities such as Wuhu, Anqing, Wuhan and Yichang, roughly parallel to G42 Shanghai-Chengdu Expressway to its south. The thoroughfare begins at Huqingping Outer Ring Interchange near Hongqiao International Airport, where it meets S20 Outer Ring Expressway in Shanghai, and terminates at an interchange in Jiangbei District, where the highway joins G75 Lanzhou-Haikou Expressway. It is fully complete and spans 1,900 km (1,200 mi) in length.

The Shanghai–Chengdu Expressway, designated as G42 and commonly referred to as the Hurong Expressway is an east–west bound expressway that connects the eastern metropolis of Shanghai to Chengdu, the capital city of Sichuan. The expressway passes through six provinces and serves major cities such as Suzhou, Wuxi, Changzhou, Nanjing, Hefei, Wuhan, and Yichang. The eastern terminus of G42 is at the Wuning Road Interchange of Shanghai Middle Ring Road. At its western terminus, the expressway intersects the East 3rd Ring Road and connects East Erxianqiao Road in Chenghua District, Chengdu. The expressway spans 1,960 km (1,220 mi) in length.