Infinite photos and videos for every Wiki article · Find something interesting to watch in seconds
History
Page
Cartoon depicting the basic concept of GPCR conformational activation. Ligand binding disrupts an ionic lock between the E/DRY motif of TM-3 and acidi
Cartoon depicting the basic concept of GPCR conformational activation. Ligand binding disrupts an ionic lock between the E/DRY motif of TM-3 and acidic residues of TM-6. As a result, the GPCR reorganizes to allow activation of G-alpha proteins. The "side perspective" is a view from above and to the side of the GPCR as it is set in the plasma membrane (the membrane lipids have been omitted for clarity). The incorrectly labelled "intracellular perspective" shows an extracellular view looking down at the plasma membrane from outside the cell.
Cartoon depicting the heterotrimeric G-protein activation/deactivation cycle in the context of GPCR signaling
Cartoon depicting the heterotrimeric G-protein activation/deactivation cycle in the context of GPCR signaling
The effect of Rs and Gs in cAMP signal pathway
The effect of Rs and Gs in cAMP signal pathway
The effect of Ri and Gi in cAMP signal pathway
The effect of Ri and Gi in cAMP signal pathway
Page
External reactions and internal reactions for signal transduction (click to enlarge)
External reactions and internal reactions for signal transduction (click to enlarge)
Three conformation states of acetylcholine receptor (click to enlarge)
Three conformation states of acetylcholine receptor (click to enlarge)
Sketch of an enzyme-linked receptor structure (structure of IGF-1R) (click to enlarge)
Sketch of an enzyme-linked receptor structure (structure of IGF-1R) (click to enlarge)
Flow charts of two strategies of structure-based drug design
Flow charts of two strategies of structure-based drug design