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WikiVisually
The entire wiki reimagined as a visual magazine with video discovery · Watch your interests come alive
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G protein-coupled receptor
Videos
G protein-coupled receptors, also known as seven--transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors, form a large group of evo
Cartoon depicting the basic concept of GPCR conformational activation. Ligand binding disrupts an ionic lock between the E/DRY motif of TM-3 and acidi
Cartoon depicting the basic concept of GPCR conformational activation. Ligand binding disrupts an ionic lock between the E/DRY motif of TM-3 and acidic residues of TM-6. As a result, the GPCR reorganizes to allow activation of G-alpha proteins. The "side perspective" is a view from above and to the side of the GPCR as it is set in the plasma membrane (the membrane lipids have been omitted for clarity). The incorrectly labelled "intracellular perspective" shows an extracellular view looking down at the plasma membrane from outside the cell.
Cartoon depicting the heterotrimeric G-protein activation/deactivation cycle in the context of GPCR signaling
Cartoon depicting the heterotrimeric G-protein activation/deactivation cycle in the context of GPCR signaling
The effect of Rs and Gs in cAMP signal pathway
The effect of Rs and Gs in cAMP signal pathway
The effect of Ri and Gi in cAMP signal pathway
The effect of Ri and Gi in cAMP signal pathway
Arrestin
Videos
Arrestins are a small family of proteins important for regulating signal transduction at G protein-coupled receptors. Arrestins were first discovered in the late '80s as a part of a conserved two-step
G protein-coupled receptor
…threonine (Thr) residues that, when phosphorylated, increase the affinity of the intracellular surface for the binding of scaffolding proteins called β-arrestins (β-arr). Once bound, β-arrestins both sterically prevent G-protein coupling and may recruit other proteins, leading to the creation of signaling complexes…
Structure of arrestin from bovine rod outer segments.
Structure of arrestin from bovine rod outer segments.
Structure of bovine beta-arrestin.
Structure of bovine beta-arrestin.
Crystal structure showing where arrestin will precisely bound to activated and phosphorylated rhodopsin at key residues
Crystal structure showing where arrestin will precisely bound to activated and phosphorylated rhodopsin at key residues