Gabriel of Melitene was an Armenian general who ruled the city of Melitene. Gabriel started his career as an officer of the Byzantine general Philaretos Brachamios, who installed him in Melitene. After the general's death, Gabriel broke away from the Byzantine Empire. He sought to ally himself with the leaders of the crusades and had his daughter, Morphia, marry Baldwin II of Edessa. He was killed after Melitene was conquered by the Seljuk Turks.

Malatya is a city in the Eastern Anatolia region of Turkey and the capital of Malatya Province. The city has been a human settlement for thousands of years.