Gaffney is a city in and the seat of Cherokee County, South Carolina, United States, in the Upstate region of South Carolina. Gaffney is known as the "Peach Capital of South Carolina". The population was 12,539 at the 2010 census, with an estimated population of 12,609 in 2019. It is the principal city of the Gaffney, South Carolina, Micropolitan Statistical Area, which includes all of Cherokee County and which is further included in the greater Greenville-Spartanburg-Anderson, South Carolina Combined Statistical Area.

The Upstate, historically known as the Upcountry, is a region of the U.S. state of South Carolina, comprising the northwesternmost area of the state. Although loosely defined among locals, the general definition includes the 10 counties of the commerce-rich I-85 corridor in the northwest corner of South Carolina. This definition coincided with the Greenville-Spartanburg-Anderson, SC Combined Statistical Area, as first defined by the Office of Management and Budget (OMB) in 2015. In 2023, the OMB issued its most updated definition of the CSA that coincides again with the 10-county region.