Gainesville is a city in and the county seat of Cooke County, Texas, United States. Its population was 17,394 at the 2020 census. It is part of the Texoma region and is an important Agri-business center.

Edmund Pendleton Gaines was a career United States Army officer who served for nearly fifty years, and attained the rank of major general by brevet. He was one of the Army's senior commanders during its formative years in the early to mid-1800s, and was a veteran of the War of 1812, Seminole Wars, Black Hawk War, and Mexican–American War.