Gaius Claudius Nero was a Roman general active during the Second Punic War against the invading Carthaginian force, led by Hannibal Barca. During a military career that began as legate in 214 BC, he was praetor in 212 BC, propraetor in 211 BC during the siege of Capua, before being sent to Spain that same year. He became consul in 207 BC.

The Second Punic War was the second of three wars fought between Carthage and Rome, the two main powers of the western Mediterranean in the 3rd century BC. For 17 years the two states struggled for supremacy, primarily in Italy and Iberia, but also on the islands of Sicily and Sardinia and, towards the end of the war, in North Africa. After immense materiel and human losses on both sides, the Carthaginians were once again defeated. Macedonia, Syracuse and several Numidian kingdoms were drawn into the fighting, and Iberian and Gallic forces fought on both sides. There were three main military theatres during the war: Italy, where Hannibal defeated the Roman legions repeatedly, with occasional subsidiary campaigns in Sicily, Sardinia and Greece; Iberia, where Hasdrubal, a younger brother of Hannibal, defended the Carthaginian colonial cities with mixed success before moving into Italy; and Africa, where Rome finally won the war.