Galena is a city in the Yukon-Koyukuk Census Area in the U.S. state of Alaska. At the 2020 census the population was 472, slightly up from 470 in 2010. Galena was established in 1918, and a military airfield was built adjacent to the city during World War II. The city was incorporated in 1971.

Yukon–Koyukuk Census Area is a census area in the U.S. state of Alaska. As of the 2020 census, the population was 5,343, down from 5,588 in 2010. With an area of 147,842.51 sq mi (382,910.3 km2), it is the largest of any county or county-equivalent in the United States, or slightly larger than the entire state of Montana. It is part of the unorganized borough of Alaska and therefore has no borough seat. Its largest communities are the cities of Galena, in the west, and Fort Yukon, in the northeast.