Galena is the largest city in and the county seat of Jo Daviess County, Illinois, United States. It had a population of 3,308 at the 2020 census. A 581-acre (235 ha) section of the city is listed on the National Register of Historic Places as the Galena Historic District. The city is named for the mineral galena, which was in the ore that formed the basis for the region's early lead mining economy.

The Illinois Central Railroad, sometimes called the Main Line of Mid-America, was a railroad in the Central United States. Its primary routes connected Chicago, Illinois, with New Orleans, Louisiana, and Mobile, Alabama, and thus, the Great Lakes to the Gulf of Mexico. Another line connected Chicago west to Sioux City, Iowa (1870), while smaller branches reached Omaha, Nebraska (1899) from Fort Dodge, Iowa, and Sioux Falls, South Dakota (1877), from Cherokee, Iowa. The IC also ran service to Miami, Florida, on trackage owned by other railroads.