The Galena Historic District is a historic district located in the city of Galena, Illinois, United States. The historic district encompasses 85 percent of the city of Galena and includes more than 800 properties. The downtown area consists of three successive tiers made up of Main, Bench and Prospect Streets. Within the boundaries of the district are such notable homes as the Ulysses S. Grant Home and the Elihu B. Washburne House. The Galena Historic District was added to the U.S. National Register of Historic Places in 1969.

Galena is the largest city in and the county seat of Jo Daviess County, Illinois, United States. It had a population of 3,308 at the 2020 census. A 581-acre (235 ha) section of the city is listed on the National Register of Historic Places as the Galena Historic District. The city is named for the mineral galena, which was in the ore that formed the basis for the region's early lead mining economy.