The Gambino crime family is an Italian-American Mafia crime family and one of the "Five Families" that dominate organized crime activities in New York City, within the nationwide criminal phenomenon known as the American Mafia. The group, which went through five bosses between 1910 and 1957, is named after Carlo Gambino, boss of the family at the time of the McClellan hearings in 1963, when the structure of organized crime first gained public attention. The group's operations extend from New York and the eastern seaboard to California. Its illicit activities include labor and construction racketeering, gambling, loansharking, extortion, money laundering, prostitution, fraud, hijacking, and fencing.

Capo dei capi or capo di tutti i capi or Godfather are terms used mainly by the media, public, fiction writers and law enforcement community to indicate a supremely powerful crime boss in the Sicilian or American Mafia who holds great influence over the whole organization. The term was introduced to the U.S. public by the Kefauver Commission in 1950.