Game theory is the study of mathematical models of strategic interactions among rational agents. It has applications in many fields of social science, used extensively in economics as well as in logic, systems science and computer science. Initially game theory addressed two-person zero-sum games, in which a participant's gains or losses are exactly balanced by the losses and gains of the other participant. In the 1950’s it was extended to the study of non zero-sum games and was eventually game applied to a wide range of behavioral relations, and is now an umbrella term for the science of rational decision making in humans, animals, as well as computers.

John von Neumann was a Hungarian and American mathematician, physicist, computer scientist, engineer and polymath. He had perhaps the widest coverage of any mathematician of his time, integrating pure and applied sciences and making major contributions to many fields, including mathematics, physics, economics, computing, and statistics. He was a pioneer in building the mathematical framework of quantum physics, in the development of functional analysis, and in game theory, introducing or codifying concepts including cellular automata, the universal constructor and the digital computer. His analysis of the structure of self-replication preceded the discovery of the structure of DNA.