Garden Ruin is the fifth studio album by the rock band Calexico. It was released in 2006 on Quarterstick Records. The LP is the first Calexico album to feature no instrumental tracks, instead relying on a more direct, pop-style approach. Forgoing what has been described as "indie-mariachi", the band took their music in a different direction, and the result is a more straightforward indie rock album.

Calexico is an American indie rock band based in Tucson, Arizona. Founded in 1996, the band's two main members, Joey Burns and John Convertino, first played together in Los Angeles as part of the group Giant Sand. They have recorded a number of albums on Quarterstick Records and City Slang, and their 2005 EP, In the Reins, recorded with Iron & Wine, reached the Billboard 200 album charts. Their musical style is influenced by traditional Latin sounds of mariachi, conjunto, cumbia, and tejano mixed with country, jazz, and post-rock.