The Genoa–Pisa railway is one of the trunk lines of the Italian railway network. It runs along the Ligurian coast from Genoa to Pisa through the Riviera di Levante and the Versilia. It passes through the cities of Massa, Carrara and La Spezia. South of Pisa the Pisa–Rome line continues along the Tyrrhenian coast to Rome. The line is double track and is fully electrified at 3,000 V DC. Passenger traffic is managed by Trenitalia.

Genoa is a city in and the capital of the Italian region of Liguria, and the sixth-largest city in Italy. In 2023, 558,745 people lived within the city's administrative limits. While its metropolitan city has 813,626 inhabitants, more than 1.5 million people live in the wider metropolitan area stretching along the Italian Riviera.