George, Duke of Mecklenburg was the head of the House of Mecklenburg-Strelitz from 1934 until his death. Through his father, he was a descendant of Emperor Paul I of Russia.

The House of Mecklenburg, also known as Nikloting, is a North German dynasty of Polabian origin that ruled until 1918 in the Mecklenburg region, being among the longest-ruling families of Europe. Queen Juliana of the Netherlands (1909–2004), former Queen of the Netherlands (1948–1980), was an agnatic member of this house.