State Route 122 (SR 122) is a 98.2-mile-long (158.0 km) state highway that travels west-to-east through portions of Thomas, Brooks, Lowndes, Lanier, Clinch, and Ware counties in the southern part of the U.S. state of Georgia. The highway connects the cities of Thomasville and Waycross, via Lakeland.

Thomas County is a county located in the U.S. state of Georgia. As of the 2020 census the population was 45,798. The county seat is Thomasville. Thomas County comprises the Thomasville, GA micropolitan statistical area.