State Route 15 (SR 15) is a 346-mile-long (557 km) state highway that travels south-to-north across the entire length of the U.S. state of Georgia, east of its centerline. This route is part of a multi two-state route 15 that begins at Florida and ends at Georgia at the North Carolina state line. It connects the Florida state line, south-southeast of Folkston with the North Carolina state line, in Dillard, via Folkston, Vidalia, Sandersville, Athens, Demorest, and Clayton.

U.S. Route 319 is a spur of US 19. It runs for 303 miles (488 km) from US 98 at the foot of the John Gorrie Memorial Bridge across from downtown Apalachicola, Florida to US 1/SR 4 in Wadley, Georgia, through the Panhandle of Florida and the southern portion of Georgia.