State Route 16 (SR 16) is a 179-mile-long (288 km) state highway that travels west-to-east through portions of Haralson, Carroll, Coweta, Spalding, Butts, Jasper, Putnam, Hancock, and Warren counties in the western and central parts of the U.S. state of Georgia. The highway connects the southeastern portion of Carroll County, northwest of Mount Zion to Warrenton, via Carrollton, Newnan, Griffin, Monticello, Eatonton, and Sparta.

Spalding County is a county located in the west central portion of the U.S. state of Georgia. As of the 2020 census, the population was 67,306. The county seat is Griffin. The county was created December 20, 1851, and named for former United States representative and senator Thomas Spalding.