The House of Ghica [or Ghika] was a noble family whose members held significant positions in Wallachia, Moldavia and later in the Kingdom of Romania, between the 17th and 19th centuries. The Ghica family produced many voivodes of Wallachia and Moldavia and two Prime Ministers of Romania. Several branches of the family still exist today.

Wallachia or Walachia is a historical and geographical region of modern-day Romania. It is situated north of the Lower Danube and south of the Southern Carpathians. Wallachia was traditionally divided into two sections, Muntenia and Oltenia. Dobruja could sometimes be considered a third section due to its proximity and brief rule over it. Wallachia as a whole is sometimes referred to as Muntenia through identification with the larger of the two traditional sections.