The House of Ghica [or Ghika] was a noble family whose members held significant positions in Wallachia, Moldavia and later in the Kingdom of Romania, between the 17th and 19th centuries. The Ghica family produced many voivodes of Wallachia and Moldavia and two Prime Ministers of Romania. Several branches of the family still exist today.

Moldavia is a historical region and former principality in Central and Eastern Europe, corresponding to the territory between the Eastern Carpathians and the Dniester River. An initially independent and later autonomous state, it existed from the 14th century to 1859, when it united with Wallachia as the basis of the modern Romanian state; at various times, Moldavia included the regions of Bessarabia, all of Bukovina and Hertsa. The region of Pokuttya was also part of it for a period of time.