Ghostbusters: The Video Game is a 2009 action-adventure game based on the Ghostbusters media franchise. Terminal Reality developed the Windows, PlayStation 3, and Xbox 360 versions, while Red Fly Studio developed the PlayStation 2, PlayStation Portable, and Wii versions. The game was released after several delays in development and multiple publisher changes. In North America, all versions of the game were published by Atari Interactive, while in Europe, the PlayStation 2, PlayStation Portable, and PlayStation 3 versions were published by Sony Computer Entertainment Europe. A separate game for the Nintendo DS with the same title was developed by Zen Studios and released at the same time, albeit with substantial differences in the gameplay and story.

The Ghostbusters franchise consists of American supernatural comedies, based on an original concept created by Dan Aykroyd and Harold Ramis in 1984. The plot follows a group of eccentric New York City parapsychologists who investigate and eliminate ghosts, paranormal manifestations, demigods, and demons. The franchise expanded with licensed action figures, books, comics, video games, television series, theme park attractions, and other branded merchandise.