Gilberto Simoni is an Italian former professional road bicycle racer, most recently for Lampre–Farnese Vini. Simoni won the Giro d'Italia cycling race twice: once in 2001 and again in 2003. In 2002 he tested positive for cocaine and was withdrawn from the race by his Saeco team; he was later cleared of any doping violation by the Italian Cycling Federation. Aside from his withdrawal in 2002, he finished on the podium in every other Giro between 1999 and 2006.

The 2006 Giro d'Italia was the 89th edition of the Giro d'Italia, one of cycling's Grand Tours. It began in the Belgian city of Seraing with a 6.2 km (3.9 mi) individual time trial. The race came to a close with a 140 km (87.0 mi) mass-start road stage that stretched from Museo del Ghisallo to Milan. Twenty two teams entered the race that was won by the Italian Ivan Basso of the Team CSC team. Second and third were the Spain José Enrique Gutiérrez and Italian Gilberto Simoni.