Gilpatrick Hotel was situated at 223 Third Street in Milwaukee, Wisconsin, in the United States. It was opened in 1907 and was operated by members of the Gilpatrick family. The hotel was the site of the attempted assassination of Theodore Roosevelt in 1912.

On October 14, 1912, former saloonkeeper John Schrank (1876–1943) attempted to assassinate former U.S. President Theodore Roosevelt while he was campaigning for the presidency in Milwaukee, Wisconsin. Schrank's bullet lodged in Roosevelt's chest after penetrating Roosevelt's steel eyeglass case and passing through a thick single-folded copy of the speech titled "Progressive Cause Greater Than Any Individual", which he was carrying in his jacket. Schrank was immediately disarmed and captured; he might have been lynched had Roosevelt not shouted for Schrank to remain unharmed. Roosevelt assured the crowd he was all right, then ordered police to take charge of Schrank and to make sure no violence was done to him.