Giovanni de' Marignolli, variously anglicized as John of Marignolli or John of Florence, was a notable 14th-century Catholic European traveller to medieval China and India.

Given textual and archaeological evidence, it is thought that thousands of Europeans lived in Imperial China during the Yuan dynasty. These were people from countries traditionally belonging to the lands of Christendom during the High to Late Middle Ages who visited, traded, performed Christian missionary work, or lived in China. This occurred primarily during the second half of the 13th century and the first half of the 14th century, coinciding with the rule of the Mongol Empire, which ruled over a large part of Eurasia and connected Europe with their Chinese dominion of the Yuan dynasty. Whereas the Byzantine Empire centered in Greece and Anatolia maintained rare incidences of correspondence with the Tang, Song and Ming dynasties of China, the Holy See sent several missionaries and embassies to the early Mongol Empire as well as to Khanbaliq, the capital of the Mongol-led Yuan dynasty of China. These contacts with the West were preceded by rare interactions between the Han dynasty and Hellenistic Greeks and Romans.